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FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
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FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
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Journal Article
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
2011
Overview
The forkhead box transcription factor A2 （FOXA2） is an important regulator in animal development and body homeostasis. However, whether FOXA2 is involved in transforming growth factor β1 （TGF-β1）-mediated epithelial- to-mesenchymal transition （EMT） and tumor metastasis remains unknown. The present study showed that in human lung cancer cell lines, the abundance of FOXA2 positively correlates with epithelial phenotypes and negatively correlates with the mesenchymal phenotypes of cells, and TGF-β1 treatment decreased FOXA2 protein level. Consistently, knockdown of FOXA2 promoted EMT and invasion of lung cancer cells, whereas overexpression of FOXA2 reduced the invasion and suppressed TGF-β1-induced EMT. In addition, knockdown of FOXA2 induced slug expression, and ectopic expression of FOXA2 inhibited slug transcription. Furthermore, we identified that FOXA2 can bind to slug promoter through a conserved binding site, and that the DNA-binding region and transactivation region II of FOXA2 are required for repression of the slug promoter. These data demonstrate that FOXA2 functions as a suppressor of tumor metastasis by inhibition of EMT.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ DNA
/ Epithelial-Mesenchymal Transition
/ Hepatocyte Nuclear Factor 3-beta - genetics
/ Hepatocyte Nuclear Factor 3-beta - metabolism
/ Hepatocyte Nuclear Factor 3-beta - physiology
/ Humans
/ Original
/ RNA, Small Interfering - metabolism
/ Snail Family Transcription Factors
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Transforming Growth Factor beta1 - pharmacology
/ Tumors
/ 肺癌细胞
/ 肿瘤转移
/ 转化生长因子
/ 转录因子
