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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

by Barrat Hernández, Alejandro Q , Gay, Cynthia L , Ruíz-Palacios, Guillermo M , Hutter, Julia , Ake, Julie A , Garcia-Fragoso, Veronica , Kingsley, Jeffrey K , Neuzil, Kathleen M , Smith, Katherine , Woo, Wayne , Florescu, Diana F , Cho, Iksung , Lane, Dakotah C , Riesenberg, Robert A , Corey, Lawrence , Áñez, Germán , Dunkle, Lisa M , Coombs, Robert W , Kotloff, Karen L , Henderson, Jeffrey A , Glenn, Gregory M , Dubovsky, Filip , Duncanson, Daniel M , McClelland, R. Scott , McArthur, Monica A , Harper, Wayne L , Jeanfreau, Robert J , McKenzie, Mark , Greninger, Alex L , Fried, David L , Musante, David B , Adelglass, Jeffrey M , Safirstein, Beth E

in Adolescent / Adult / Age / Aged / Clinical trials / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - diagnosis / COVID-19 - epidemiology / COVID-19 - prevention & control / COVID-19 Nucleic Acid Testing / COVID-19 vaccines / COVID-19 Vaccines - adverse effects / Disease prevention / Genomes / Humans / Incidence / Infections / Infectious Disease / Male / Medical laboratories / Mexico / Middle Aged / Nanoparticles / Original / Pandemics / Placebos / Polymerase chain reaction / Population / Proteins / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Single-Blind Method / Site selection / Spike protein / Statistical analysis / United States / Vaccine Efficacy / Vaccines

2022

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2022

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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

2022

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Journal Article

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

Barrat Hernández, Alejandro Q,

Gay, Cynthia L,

Ruíz-Palacios, Guillermo M,

Hutter, Julia,

Ake, Julie A,

Garcia-Fragoso, Veronica,

Kingsley, Jeffrey K,

Neuzil, Kathleen M,

Smith, Katherine,

Woo, Wayne,

Florescu, Diana F,

Cho, Iksung,

Lane, Dakotah C,

Riesenberg, Robert A,

Corey, Lawrence,

Áñez, Germán,

Dunkle, Lisa M,

Coombs, Robert W,

Kotloff, Karen L,

Henderson, Jeffrey A,

Glenn, Gregory M,

Dubovsky, Filip,

Duncanson, Daniel M,

McClelland, R. Scott,

McArthur, Monica A,

Harper, Wayne L,

Jeanfreau, Robert J,

McKenzie, Mark,

Greninger, Alex L,

Fried, David L,

Musante, David B,

Adelglass, Jeffrey M,

Safirstein, Beth E

2022

Overview

NVX-CoV2373 is a vaccine containing a full-length stabilized recombinant spike protein trimer that is administered in two doses 3 weeks apart along with a saponin-based adjuvant. In a randomized trial, approximately 20,000 participants received the vaccine and 10,000 a placebo. Vaccine efficacy against infection was 90%, and reactogenicity was similar to that of other Covid-19 vaccines.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Age

/ Aged

/ Clinical trials

/ Coronavirus

/ Coronaviruses