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High HLA-DP Expression and Graft-versus-Host Disease
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Journal Article
High HLA-DP Expression and Graft-versus-Host Disease
2015
Overview
When the donor and recipient are mismatched at HLA-DPB1, the risk of graft-versus-host disease is high. The authors found that when the donor has a particular regulatory allele that lowers expression of HLA-DPB1, the risk of GVHD is lower.
Hematopoietic-cell transplantation from unrelated donors can cure blood disorders; however, graft-versus-host disease (GVHD) remains a major impediment to successful outcomes.
1
GVHD can occur after HLA-matched transplantation when the donor cells recognize polymorphic peptides (“minor histocompatibility antigens”) presented by the recipient’s HLA.
2
In HLA-mismatched transplantation, direct recognition of the recipient’s mismatched HLA by the donor’s cells provides a potent stimulus for graft-versus-host allorecognition
3
–
7
; recognition of the donor’s mismatched HLA by the recipient’s immune system leads to graft rejection.
8
,
9
The importance of HLA class II alloantigens was established early in the history of clinical transplantation.
10
Advances in understanding the . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Alleles
/ Antigens
/ Cancer
/ DNA
/ Female
/ Genotype
/ Graft vs Host Disease - genetics
/ Graft vs Host Disease - immunology
/ Hematopoietic Stem Cell Transplantation - adverse effects
/ Histocompatibility antigen HLA
/ HIV
/ HLA-DP beta-Chains - genetics
/ HLA-DP beta-Chains - metabolism
/ Human immunodeficiency virus
/ Humans
/ Leukemia
/ Male
/ Polymorphism, Single Nucleotide
