Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery

by Ferreri, Maria Cristina , Carissimi, Guzmán , Villora, Gloria , Santos, Ana Cláudia , Collado-González, Mar , Ferreira, Nuno R. , Veiga, Francisco , Sequeira, Joana A. D. , Díaz Baños, F. Guillermo , Ribeiro, Antonio , Freitas, Alessandra R.

in Aggregation / alginate polysaccharide nanocomposite / Alginates / Alginic acid / Biopolymers / Bovine serum albumin / Calcium alginate / Calcium ions / Chitosan / Dextran / Dextran sulfate / Dextrans / Diabetes / Drug delivery systems / drugs / electrolytes / Electron microscopy / electrostatic interactions / Electrostatic properties / Ethylene glycol / gelation / High-performance liquid chromatography / HPLC / Hydrodynamics / Insulin / Ionic strength / Light scattering / Liquid chromatography / lumisizer / Molecular weight / Nanocomposites / Nanoparticles / Photon correlation spectroscopy / Poloxamers / Polyelectrolytes / Polyethylene glycol / Polymers / Polysaccharides / Proteins / Scanning electron microscopy / Seaweed meal / Serum / Serum albumin / Stability / Stability analysis / Synthesis

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery

2020

Confirm

Do you wish to request the book?

Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery

Ferreri, Maria Cristina,

Carissimi, Guzmán,

Villora, Gloria,

Santos, Ana Cláudia,

Collado-González, Mar,

Ferreira, Nuno R.,

Veiga, Francisco,

Sequeira, Joana A. D.,

Díaz Baños, F. Guillermo,

Ribeiro, Antonio,

Freitas, Alessandra R.

2020

Overview

Polyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethylene glycol) 4000, poloxamer 188, chitosan, and bovine serum albumin. The nanocomposites were obtained by Ca2+-induced gelation of alginate followed by an electrostatic-interaction process among the polyelectrolytes. Chitosan seemed to be essential for the final size of the nanocomposites and there was an optimal content that led to the synthesis of nanocomposites of 400–600 nm hydrodynamic size. The enhanced stability of the synthesized nanocomposites was assessed with LUMiSizer after synthesis. Nanocomposite stability over time and under variations of ionic strength and pH were assessed with dynamic light scattering. The rounded shapes of nanocomposites were confirmed by scanning electron microscopy. After loading with insulin, analysis by HPLC revealed complete drug release under physiologically simulated conditions.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

Aggregation

/ alginate polysaccharide nanocomposite

/ Alginates

/ Alginic acid

/ Biopolymers

/ Bovine serum albumin

/ Calcium alginate