Journal Article

Radiofrequency Ablation in Barrett's Esophagus with Dysplasia

Hoffman, Brenda J, Gordon, Stuart R, Mashimo, Hiroshi, Siddiqui, Ali A, Falk, Gary W, Sharma, Prateek, Fennerty, M. Brian, Galanko, Joseph A, Wolfsen, Herbert C, Eisen, Glenn M, Souza, Rhonda F, Bronner, Mary P, Infantolino, Anthony, Hunter, John G, Rothstein, Richard I, Overholt, Bergein F, Jobe, Blair A, Muthusamy, V. Raman, Goldblum, John R, Chak, Amitabh, Chang, Kenneth J, Shaheen, Nicholas J, Fleischer, David E, Madanick, Ryan D, Hawes, Robert H, Bennett, Ana E, Lightdale, Charles J, Sampliner, Richard E, Kimmey, Michael B, Sharma, Virender K, Wang, Kenneth K, Edmundowicz, Steven A, Spechler, Stuart J

2009

Overview

In this sham-controlled, randomized trial involving patients with dysplastic Barrett's esophagus, patients who were treated with radiofrequency ablation were more likely to have complete eradication of dysplasia and intestinal metaplasia and less likely to progress to more severe dysplasia or cancer. Adverse events included chest pain and esophageal stricture. Patients with dysplastic Barrett's esophagus who were treated with radiofrequency ablation were more likely to have complete eradication of dysplasia and intestinal metaplasia and less likely to progress to more severe dysplasia or cancer. Barrett's esophagus is defined as metaplasia of the esophageal epithelium, with normal squamous epithelium replaced by columnar epithelium containing goblet cells, also known as intestinal metaplasia (Figure 1A). 1 This change is associated with gastroesophageal reflux disease. 2 Approximately 10% of patients with chronic reflux have Barrett's esophagus, 3 , 4 and the prevalence of the condition in a recent population study was 1.6%. 5 The condition is associated with an increased risk of esophageal adenocarcinoma. 6 , 7 The incidence of this once rare cancer has increased by more than 500% since the 1970s. 8 The cancer remains highly lethal, with a 5-year survival rate of less . . .

• Publisher: Massachusetts Medical Society
• Subject: Aged / Aged, 80 and over / Barrett Esophagus - pathology / Barrett Esophagus - surgery / Biological and medical sciences / Cancer / Catheter Ablation - adverse effects / Disease Progression / Esophagus / Esophagus - pathology / Esophagus - surgery / Female / General aspects / Humans / Logistic Models / Male / Medical sciences / Metaplasia - surgery / Middle Aged / Other treatments / Patients / Throat / Treatment Outcome / Treatment. General aspects / Tumors