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Journal Article
Can augmented renal clearance be detected using estimators of glomerular filtration rate?
2020
Overview
Estimators of glomerular filtration rate (GFR) have been shown to be flawed in critically ill patients, especially for augmented renal clearance (ARC), commonly defined as a measured urinary creatinine clearance (CrCl) ≥ 130 ml/min/1.73 m2 [1]. [...]measuring CrCl should be performed in daily practice on the intensive care unit (ICU). [...]the aim of this study is to define the most precise GFR estimator, which can then be used to detect ARC when measured CrCl is unavailable. [...]the performance of these cut-offs was evaluated in an external single-center (Leuven, January 2016–December 2016) validation set by receiver-operating characteristics (ROC) curve analysis, using 2000 bootstrap replicates.
Publisher
BioMed Central,Springer Nature B.V,BMC
