Journal Article

Baseline Characteristics from UNITE: An Observational, International, Multicentre Registry to Evaluate Hidradenitis Suppurativa (Acne Inversa) in Clinical Practice

Paller, Amy S., Kerdel, Francisco, Duan, Yinghui, Kimball, Alexa B., Teixeira, Henrique D., Longcore, Michelle, Prens, Errol P., Lugo-Somolinos, Aida M.

2020

Overview

Background Hidradenitis suppurativa (HS), also known as acne inversa, is a recurring, painful, chronic, and sometimes disfiguring inflammatory skin disease. Objectives Our objective was to report the baseline clinical characteristics, natural history, and associated outcomes of patients with HS from the ongoing, prospective, non-interventional UNITE registry that is collecting data regarding the natural history and associated outcomes of HS. Methods Patients with inflammatory HS lesions were enrolled, including adolescents (aged 12 to < 18 years) and adults (aged ≥ 18 years). None had participated in previous or current originator-adalimumab studies/registries. Patients received treatment consistent with site-specific, routine clinical practice. HS disease status was assessed by HS lesions and disease flare; treatment and outcomes data were collected at enrolment and every 6 months for ≤ 4 years. Results Enrolment ( N  = 594; 89.1% adults; 10.9% adolescents) occurred from 29 October 2013 to 29 December 2015 at 73 sites in 12 countries. At baseline, the majority were female (69.7%) and White (81.2%), had moderate-to-severe disease (Hurley stage II or III; 93.3%), and had undergone prior procedures/surgery for HS (68.7%). In total, 61.6% of adults and 49.2% of adolescents were obese; 40.2% of patients reported current tobacco use. Scarring due to lesions occurred in 91.2% of patients. The prevalence of comorbidities of interest was as follows: depression (13.3%), other psychiatric disorders (9.6%), inflammatory bowel disease (2.7%), diabetes (9.1%), and polycystic ovary syndrome (5.2%). Conclusions In this population from the UNITE HS registry, obesity and smoking were common, and disease burden was high, manifesting as multiple lesions, scarring, surgical history, and considerable comorbidities.

• Publisher: Springer International Publishing,Springer Nature B.V
• Subject: Abscesses / Acne / Adolescent / Adult / Aged / Body mass index / Child / Cicatrix - epidemiology / Cicatrix - etiology / Cicatrix - prevention & control / Clinical medicine / Comorbidity / Cost of Illness / Dermatology / Female / Fistula / Hidradenitis Suppurativa - complications / Hidradenitis Suppurativa - diagnosis / Hidradenitis Suppurativa - epidemiology / Hidradenitis Suppurativa - therapy / Humans / Inflammatory bowel disease / Male / Medicine / Medicine & Public Health / Middle Aged / Monoclonal antibodies / Natural history / Non-pharmacological intervention / Obesity / Obesity - epidemiology / Original / Original Research Article / Ovaries / Patients / Pharmacology/Toxicology / Pharmacotherapy / Polycystic ovary syndrome / Practice Patterns, Physicians' - statistics & numerical data / Prevalence / Prospective Studies / Quality of life / Registries - statistics & numerical data / Risk Factors / Severity of Illness Index / Skin / Skin diseases / Smoking - epidemiology / Teenagers / Tobacco / Treatment Outcome / Weight control / Young Adult