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Corneal Langerhans cells in children with celiac disease
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Corneal Langerhans cells in children with celiac disease
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Journal Article
Corneal Langerhans cells in children with celiac disease
2022
Overview
Celiac disease (CeD) is a common small bowel enteropathy characterized by an altered adaptive immune system and increased mucosal antigen presenting cells. This study aims to establish if quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) could act as a surrogate marker for antigen presenting cell status and hence disease activity in children with CeD. Twenty children with stable CeD and 20 age-matched controls underwent CCM and quantification of central corneal total, mature and immature LC density. There was no difference in age (11.78 ± 1.7 vs. 12.83 ± 1.91;
P
= 0.077) or height (1.38 ± 0.14 vs. 1.44 ± 0.13;
P
= 0.125). BMI (18.81 ± 3.90 vs. 22.26 ± 5.47;
P
= 0.031) and 25 OHD levels (43.50 ± 13.36 vs. 59.77 ± 22.45;
P
= 0.014) were significantly lower in children with CeD compared to controls. The total (33.33(16.67–59.37) vs. 51.56(30.21–85.42);
P
= 0.343), immature (33.33(16.67–52.08) vs. 44.79(29.17–82.29);
P
= 0.752) and mature (1.56(0–5) vs. 1.56(1.04–8.33);
P
= 0.752) LC density did not differ between the CeD and control groups. However, immature (r = 0.535,
P
= 0.015), mature (r = 0.464,
P
= 0.039), and total (r = 0.548,
P
= 0.012) LC density correlated with age. Immature (r = 0.602,
P
= 0.038) and total (r = 0.637,
P
= 0.026) LC density also correlated with tissue transglutaminase antibody (Anti-TtG) levels assessed in 12/20 subjects with CeD. There was no difference in corneal LC density between children with CeD and controls. However, the correlation between corneal LC density and anti-TtG levels suggests a relationship with disease activity in CeD and requires further study.
