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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
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Journal Article
Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
2020
Overview
Optical probes operating in the second near-infrared window (NIR-II, 1,000-1,700 nm), where tissues are highly transparent, have expanded the applicability of fluorescence in the biomedical field. NIR-II fluorescence enables deep-tissue imaging with micrometric resolution in animal models, but is limited by the low brightness of NIR-II probes, which prevents imaging at low excitation intensities and fluorophore concentrations. Here, we present a new generation of probes (Ag
2
S superdots) derived from chemically synthesized Ag
2
S dots, on which a protective shell is grown by femtosecond laser irradiation. This shell reduces the structural defects, causing an 80-fold enhancement of the quantum yield. PEGylated Ag
2
S superdots enable deep-tissue in vivo imaging at low excitation intensities (<10 mW cm
−2
) and doses (<0.5 mg kg
−1
), emerging as unrivaled contrast agents for NIR-II preclinical bioimaging. These results establish an approach for developing superbright NIR-II contrast agents based on the synergy between chemical synthesis and ultrafast laser processing.
Deep tissue imaging has been limited by the low brightness of probes emitting in the second near-infrared window. Here, the authors use femtosecond laser irradiation to grow a protective shell on Ag
2
S nanoparticles, achieving 80-fold quantum yield enhancement and imaging with low excitation intensities.
