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ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients
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ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients
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Journal Article
ATF3 deficiency impairs the proliferative–secretory phase transition and decidualization in RIF patients
2021
Overview
Decidualization is a complex process involving cellular proliferation and differentiation of the endometrial stroma and is required to establish and support pregnancy. Dysregulated decidualization has been reported to be a critical cause of recurrent implantation failure (RIF). In this study, we found that Activating transcription factor 3 (ATF3) expression was significantly downregulated in the endometrium of RIF patients. Knockdown of ATF3 in human endometrium stromal cells (hESCs) hampers decidualization, while overexpression could trigger the expression of decidual marker genes, and ameliorate the decidualization of hESCs from RIF patients. Mechanistically, ATF3 promotes decidualization by upregulating FOXO1 via suppressing miR-135b expression. In addition, the endometrium of RIF patients was hyperproliferative, while overexpression of ATF3 inhibited the proliferation of hESCs through CDKN1A. These data demonstrate the critical roles of endometrial ATF3 in regulating decidualization and proliferation, and dysregulation of ATF3 in the endometrium may be a novel cause of RIF and therefore represent a potential therapeutic target for RIF.
Publisher
Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
Subject
/ 13/109
/ 13/51
/ 13/89
/ 14/19
/ 38/77
/ 38/89
/ 38/90
/ 38/91
/ 45/15
/ 692/308
/ Activating transcription factor 3
/ Activating Transcription Factor 3 - deficiency
/ Activating Transcription Factor 3 - genetics
/ Activating Transcription Factor 3 - metabolism
/ Biomedical and Life Sciences
/ Cell Proliferation - physiology
/ Decidua
/ Embryo Implantation - physiology
/ Female
/ Forkhead Box Protein O1 - genetics
/ Forkhead Box Protein O1 - metabolism
/ Humans
