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Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates
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Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates
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Journal Article
Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates
2021
Overview
Acinetobacter baumannii
has emerged worldwide as a dominant pathogen in a broad range of severe infections, raising an acute need for efficient antibacterials. This is the first report on the resistome and virulome of 33 extended drug-resistant and carbapenem-resistant
A. baumannii
(XDR CRAB) strains isolated from hospitalized and ambulatory patients in Bucharest, Romania. A total of 33 isolates were collected and analyzed using phenotypic antibiotic susceptibility and conjugation assays, PCR, whole-genome sequencing (WGS), pulsed-field gel electrophoresis (PFGE) and MultiLocus Sequence Typing (MLST). All isolates were extensively drug-resistant (XDR), being susceptible only to colistin. The carbapenem resistance was attributed by PCR mainly to
bla
OXA-24
and
bla
OXA-23
genes. PFGE followed by MLST analysis demonstrated the presence of nine pulsotypes and six sequence types. WGS of seven XDR CRAB isolates from healthcare-associated infections demonstrated the high diversity of resistance genes repertoire, as well as of mobile genetic elements, carrying ARGs for aminoglycosides, sulphonamides and macrolides. Our data will facilitate the understanding of resistance, virulence and transmission features of XDR AB isolates from Romanian patients and might be able to contribute to the implementation of appropriate infection control measures and to develop new molecules with innovative mechanisms of action, able to fight effectively against these bugs, for limiting the spread and decreasing the infection rate and mortality.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - genetics
/ Acinetobacter baumannii - isolation & purification
/ Acinetobacter baumannii - pathogenicity
/ Acinetobacter Infections - drug therapy
/ Acinetobacter Infections - microbiology
/ Anti-Bacterial Agents - therapeutic use
/ Colistin
/ Drug Resistance, Bacterial - genetics
/ Electrophoresis, Gel, Pulsed-Field
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Pulsed-field gel electrophoresis
/ Science
