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Thirty-year clinical experience in gamma knife radiosurgery for trigeminal schwannomas
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Thirty-year clinical experience in gamma knife radiosurgery for trigeminal schwannomas
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Journal Article
Thirty-year clinical experience in gamma knife radiosurgery for trigeminal schwannomas
2022
Overview
We aimed to evaluate the radiographic and clinical outcomes after gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). A total of 87 patients who underwent GKRS for TSs between 1990 and 2020 were enrolled. The mean tumor volume was 4.3 cm
3
. The median prescribed dose for the margins of the tumor was 13 Gy. The median follow-up duration was 64.3 months (range 12.0–311.5 months). The overall local tumor control rate was 90%, and the symptom response rate was 93%. The response rate for each symptom was 88% for facial pain, 97% for facial sensory change, and 86% for cranial nerve deficits. Nineteen (22%) patients showed transient swelling, which had regressed at the time of the last follow-up. Cystic tumors were associated with transient swelling (
p
= 0.04). A tumor volume of < 2.7 cm
3
was associated with local tumor control in univariable analysis. Transient swelling was associated with symptom control failure in both univariable and multivariable analyses (
p
= 0.04, odds ratio 14.538). GKRS is an effective treatment for TSs, both for local control and symptom control.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4028
/ 692/617
/ Cranial Nerve Neoplasms - diagnostic imaging
/ Cranial Nerve Neoplasms - radiotherapy
/ Cranial Nerve Neoplasms - surgery
/ Humanities and Social Sciences
/ Humans
/ Neurilemmoma - diagnostic imaging
/ Patients
/ Radiosurgery - instrumentation
/ Science
/ Trigeminal Nerve Diseases - diagnostic imaging
/ Trigeminal Nerve Diseases - radiotherapy
/ Trigeminal Nerve Diseases - surgery
/ Tumors
