Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis

by Chen, Menglin , Dong, Mingdong , Besenbacher, Flemming , Muhammad, Hanif , Xu, Ruodan , Zhao, Huiling

in 13/107 / 14/19 / 38/77 / 631/532/1360 / 631/61/54/152 / Adipogenesis / Cell proliferation / Chondrogenesis / Connective tissue growth factor / Electron microscopy / Fibers / Fibroblast growth factor 2 / Fluorescence microscopy / Fourier transforms / Growth factors / Humanities and Social Sciences / Infrared spectroscopy / Mesenchyme / multidisciplinary / Osteogenesis / Polyethylene / Polyethylene oxide / Science / Science (multidisciplinary) / Silk / Stem cell transplantation / Stem cells / Transmission electron microscopy / Transplantation

2017

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis

by Chen, Menglin , Dong, Mingdong , Besenbacher, Flemming , Muhammad, Hanif , Xu, Ruodan , Zhao, Huiling

2017

Confirm

Do you wish to request the book?

Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis

by Chen, Menglin , Dong, Mingdong , Besenbacher, Flemming , Muhammad, Hanif , Xu, Ruodan , Zhao, Huiling

2017

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis

Chen, Menglin,

Dong, Mingdong,

Besenbacher, Flemming,

Muhammad, Hanif,

Xu, Ruodan,

Zhao, Huiling

2017

Overview

The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolactone)-polyethylene oxide (SF/PLCL-PEO) enhanced fibrogenic lineage differentiation of MSCs. The core-shell structure was confirmed by transmission electron microscopy (TEM), fluorescence microscopy and attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy. A sequential release of FGF-2 and CTGF was successfully achieved in this manner. FGF-2 plays an important role in stem cell proliferation and, meanwhile when accompanied with CTGF, has a slightly additive effect on fibrogenic differentiation of MSCs, whereas CTGF promotes fibrogenesis and alleviates osteogenesis, chondrogenesis and adipogenesis.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

13/107

/ 14/19

/ 38/77