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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
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Journal Article
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
2020
Overview
Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at
https://exbio.wzw.tum.de/covex/
.
Information developed to understand the molecular mechanisms of SARS-CoV-2 infection for predicting drug repurposing candidates is time-consuming to integrate and explore. Here, the authors develop an interactive online platform for virus-host interactome exploration and drug (target) identification.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Antiviral Agents - therapeutic use
/ Betacoronavirus - drug effects
/ Coronavirus Infections - drug therapy
/ COVID-19
/ Drug Repositioning - methods
/ Host Microbial Interactions - physiology
/ Humanities and Social Sciences
/ Humans
/ Internet
/ Medicine
/ Pneumonia, Viral - drug therapy
/ Proteins
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Virus Attachment - drug effects
/ Viruses
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