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Acinetobacter baylyi regulates type IV pilus synthesis by employing two extension motors and a motor protein inhibitor
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Acinetobacter baylyi regulates type IV pilus synthesis by employing two extension motors and a motor protein inhibitor
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Journal Article
Acinetobacter baylyi regulates type IV pilus synthesis by employing two extension motors and a motor protein inhibitor
2021
Overview
Bacteria use extracellular appendages called type IV pili (T4P) for diverse behaviors including DNA uptake, surface sensing, virulence, protein secretion, and twitching motility. Dynamic extension and retraction of T4P is essential for their function, and T4P extension is thought to occur through the action of a single, highly conserved motor, PilB. Here, we develop
Acinetobacter baylyi
as a model to study T4P by employing a recently developed pilus labeling method. By contrast to previous studies of other bacterial species, we find that T4P synthesis in
A. baylyi
is dependent not only on PilB but also on an additional, phylogenetically distinct motor, TfpB. Furthermore, we identify a protein (CpiA) that inhibits T4P extension by specifically binding and inhibiting PilB but not TfpB. These results expand our understanding of T4P regulation and highlight how inhibitors might be exploited to disrupt T4P synthesis.
Type IV pili (T4P) are retractile appendages used by bacteria for DNA uptake and other purposes. T4P extension is thought to occur through the action of a single motor protein, PilB. Here, Ellison et al. show that T4P synthesis in
Acinetobacter baylyi
depends not only on PilB but also on an additional, distinct motor, TfpB.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 49/47
/ Bacteria
/ Biological Transport - physiology
/ DNA
/ Fimbriae Proteins - antagonists & inhibitors
/ Fimbriae Proteins - genetics
/ Fimbriae Proteins - metabolism
/ Fimbriae, Bacterial - physiology
/ Gene Expression Regulation, Bacterial - genetics
/ Humanities and Social Sciences
/ Molecular Motor Proteins - antagonists & inhibitors
/ Molecular Motor Proteins - genetics
/ Molecular Motor Proteins - metabolism
/ Pili
/ Proteins
/ Science
