Journal Article

Liquid biopsy in gastric cancer: predictive and prognostic biomarkers

Chong, Wei, Li, Leping, Zhang, Zihao, Wu, Hao, Jing, Changqing, Shang, Liang

2022

Overview

Gastric cancer (GC) is a high-incidence cancer worldwide. Most patients are diagnosed at an advanced stage, by which time they have limited treatment options and poor prognosis. Early diagnosis and precise treatment are important. In the past few years, emerging research has been conducted on the use of non-invasive liquid biopsy, with its advantages of minimal invasiveness and repeated sampling, to monitor tumor occurrence and recurrence in real time and to evaluate prognosis and treatment response. Many studies have demonstrated the potential of liquid biopsy in GC, and the detection of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating free DNA (cfDNA), and exosomes has achieved gratifying results. In this review, we summarize evolving technologies for and information regarding liquid biopsy, the most recently discovered GC liquid biopsy biomarkers, and ongoing clinical trials and discuss the challenges and application prospects of liquid biopsy in GC.

• Publisher: Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
• Subject: 631/67/1504/1829 / 692/53/2421 / 692/53/2423 / Antibodies / Apoptosis / Biochemistry / Biomarkers / Biomarkers, Tumor - genetics / Biomedical and Life Sciences / Biopsy / Cancer therapies / Cell Biology / Cell Culture / Circulating Tumor DNA - genetics / Clinical trials / DNA methylation / Exosomes / Gastric cancer / Gastrointestinal surgery / Humans / Immunology / Invasiveness / Life Sciences / Liquid Biopsy - methods / Liver cancer / Medical diagnosis / Medical prognosis / Mutation / Neoplastic Cells, Circulating - pathology / Patients / Prognosis / Prostate cancer / Review / Review Article / Stomach Neoplasms - diagnosis / Stomach Neoplasms - genetics / Tumor cells / Tumors