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High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting
by
Yao, Danyu
, Liu, Kezhou
, Yue, Xiuyan
, Shi, Tingchun
, Wang, Haoxuan
, Li, Meiqi
in
3-D printers
/ 631/61/2035
/ 639/166/985
/ 639/301/54/2295
/ 639/301/54/990
/ 639/301/54/994
/ Alginic acid
/ Bioprinting - methods
/ Cell proliferation
/ Cell viability
/ Extracellular Matrix
/ Gelatin
/ Humanities and Social Sciences
/ Hydrogels - pharmacology
/ Ink
/ Microenvironments
/ Molecular Weight
/ multidisciplinary
/ Printing
/ Printing, Three-Dimensional
/ Science
/ Science (multidisciplinary)
/ Thinning
/ Tissue Engineering - methods
/ Tissue Scaffolds
2022
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High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting
by
Yao, Danyu
, Liu, Kezhou
, Yue, Xiuyan
, Shi, Tingchun
, Wang, Haoxuan
, Li, Meiqi
in
3-D printers
/ 631/61/2035
/ 639/166/985
/ 639/301/54/2295
/ 639/301/54/990
/ 639/301/54/994
/ Alginic acid
/ Bioprinting - methods
/ Cell proliferation
/ Cell viability
/ Extracellular Matrix
/ Gelatin
/ Humanities and Social Sciences
/ Hydrogels - pharmacology
/ Ink
/ Microenvironments
/ Molecular Weight
/ multidisciplinary
/ Printing
/ Printing, Three-Dimensional
/ Science
/ Science (multidisciplinary)
/ Thinning
/ Tissue Engineering - methods
/ Tissue Scaffolds
2022
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High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting
by
Yao, Danyu
, Liu, Kezhou
, Yue, Xiuyan
, Shi, Tingchun
, Wang, Haoxuan
, Li, Meiqi
in
3-D printers
/ 631/61/2035
/ 639/166/985
/ 639/301/54/2295
/ 639/301/54/990
/ 639/301/54/994
/ Alginic acid
/ Bioprinting - methods
/ Cell proliferation
/ Cell viability
/ Extracellular Matrix
/ Gelatin
/ Humanities and Social Sciences
/ Hydrogels - pharmacology
/ Ink
/ Microenvironments
/ Molecular Weight
/ multidisciplinary
/ Printing
/ Printing, Three-Dimensional
/ Science
/ Science (multidisciplinary)
/ Thinning
/ Tissue Engineering - methods
/ Tissue Scaffolds
2022
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High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting
Journal Article
High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting
2022
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Overview
The development of 3D printing has recently attracted significant attention on constructing complex three-dimensional physiological microenvironments. However, it is very challenging to provide a bio-ink with cell-harmless and high mold accuracy during extrusion in 3D printing. To overcome this issue, a technique improving the shear-thinning performance of semi-IPN bio-ink, which is universally applicable to all alginate/gelatin-based materials, was developed. Semi-IPN bio-ink prepared by cyclic heating–cooling treatment in this study can reduce the cell damage without sacrificing the accuracy of the scaffolds for its excellent shear-thinning performance. A more than 15% increase in post-printing Cell viability verified the feasibility of the strategy. Moreover, the bio-ink with low molecular weight and wide molecular weight distribution also promoted a uniform cell distribution and cell proliferation in clusters. Overall, this strategy revealed the effects of molecular parameters of semi-IPN bio-inks on printing performance, and the cell activity was studied and it could be widely applicable to construct the simulated extracellular matrix with various bio-inks.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
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