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Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning
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Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning
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Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning
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Journal Article
Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning
2021
Overview
In animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which enables correct positioning of the anatomical structures. The most ancient axis patterning system acting across animal phyla relies on β-catenin signaling, which directs gastrulation, and patterns the main body axis. However, within Bilateria, the patterning logic varies significantly between protostomes and deuterostomes. To deduce the ancestral principles of β-catenin-dependent axial patterning, we investigate the oral–aboral axis patterning in the sea anemone
Nematostella
—a member of the bilaterian sister group Cnidaria. Here we elucidate the regulatory logic by which more orally expressed β-catenin targets repress more aborally expressed β-catenin targets, and progressively restrict the initially global, maternally provided aboral identity. Similar regulatory logic of β-catenin-dependent patterning in
Nematostella
and deuterostomes suggests a common evolutionary origin of these processes and the equivalence of the cnidarian oral–aboral and the bilaterian posterior–anterior body axes.
The authors show in
Nematostella
that the more orally expressed β-catenin targets repress the more aborally expressed β-catenin targets, thus patterning the oral-aboral axis. This likely represents the common mechanism of β-catenin-dependent axial patterning shared by Cnidaria and Bilateria.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
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