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High-resolution positron emission microscopy of patient-derived tumor organoids
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High-resolution positron emission microscopy of patient-derived tumor organoids
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High-resolution positron emission microscopy of patient-derived tumor organoids
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Journal Article
High-resolution positron emission microscopy of patient-derived tumor organoids
2021
Overview
Tumor organoids offer new opportunities for translational cancer research, but unlike animal models, their broader use is hindered by the lack of clinically relevant imaging endpoints. Here, we present a positron-emission microscopy method for imaging clinical radiotracers in patient-derived tumor organoids with spatial resolution 100-fold better than clinical positron emission tomography (PET). Using this method, we quantify
18
F-fluorodeoxyglucose influx to show that patient-derived tumor organoids recapitulate the glycolytic activity of the tumor of origin, and thus, could be used to predict therapeutic response in vitro. Similarly, we measure sodium-iodine symporter activity using
99m
Tc- pertechnetate and find that the iodine uptake pathway is functionally conserved in organoids derived from thyroid carcinomas. In conclusion, organoids can be imaged using clinical radiotracers, which opens new possibilities for identifying promising drug candidates and radiotracers, personalizing treatment regimens, and incorporating clinical imaging biomarkers in organoid-based co-clinical trials.
Positron emission tomography (PET) radiotracers measure the metabolic activity in cancer cells in patients. Here, the authors develop a microscopy method to image organoids using clinical radiotracers, which allows a direct comparison to PET imaging in patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/100
/ 13/106
/ 14
/ 14/19
/ 14/32
/ 14/34
/ 14/63
/ 59
/ 59/78
/ 96
/ Adult
/ Aged
/ Animals
/ Cancer
/ Glucose
/ Humanities and Social Sciences
/ Humans
/ Iodine
/ Organoids - diagnostic imaging
/ Patients
/ Positron emission tomography
/ Positron-Emission Tomography - methods
/ Science
/ Thyroid
/ Thyroid Neoplasms - diagnostic imaging
/ Thyroid Neoplasms - pathology
/ Tomography, Emission-Computed, Single-Photon
/ Tumors
