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miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p
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miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p
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Journal Article
miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p
2017
Overview
microRNAs (miRNAs) are tightly regulated during T lymphocyte activation to enable the establishment of precise immune responses. Here, we analyzed the changes of the miRNA profiles of T cells in response to activation by cognate interaction with dendritic cells. We also studied mRNA targets common to miRNAs regulated in T cell activation.
pik3r1
gene, which encodes the regulatory subunits of PI3K p50, p55 and p85, was identified as target of miRNAs upregulated after T cell activation. Using 3′UTR luciferase reporter-based and biochemical assays, we showed the inhibitory relationship between miR-132-3p upregulation and expression of the
pik3r1
gene. Our results indicate that specific miRNAs whose expression is modulated during T cell activation might regulate PI3K signaling in T cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
1-Phosphatidylinositol 3-kinase
/ 13/106
/ 13/109
/ 13/31
/ 38/39
/ 45/61
/ 45/77
/ 45/90
/ 82/29
/ Animals
/ CD4-Positive T-Lymphocytes - metabolism
/ Class Ia Phosphatidylinositol 3-Kinase - metabolism
/ Humanities and Social Sciences
/ Humans
/ miRNA
/ mRNA
/ Science
/ Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
