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The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress
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Journal Article
The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress
2022
Overview
The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs to coordinate systemic energy balance. However, the gut-derived hormones affecting metabolic and behavioral responses are poorly defined. Here we show that the endocrine cells of the
Drosophila
gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a
Drosophila
somatostatin homolog. Gut-derived allatostatin C induces secretion of glucagon-like adipokinetic hormone to coordinate food intake and energy mobilization. Loss of gut
Allatostatin C
or its receptor in the adipokinetic-hormone-producing cells impairs lipid and sugar mobilization during fasting, leading to hypoglycemia. Our findings illustrate a nutrient-responsive endocrine mechanism that maintains energy homeostasis under nutrient-stress conditions, a function that is essential to health and whose failure can lead to metabolic disorders.
Intestinal nutrient-sensing is important in metabolic control. Here the authors show that the gut-derived hormone Allatostatin C, a somatostatin homolog in fruit flies, links enteric nutrient sensing to behavioral and metabolic adaptations that maintain energetic homeostasis in Drosophila melanogaster.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/89
/ 14/19
/ 38/77
/ 38/90
/ 45/41
/ 64/24
/ 82/51
/ 96
/ Animals
/ Animals, Genetically Modified
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - metabolism
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Energy Metabolism - genetics
/ Energy Metabolism - physiology
/ Enteroendocrine Cells - metabolism
/ Food
/ Gastrointestinal Hormones - genetics
/ Gastrointestinal Hormones - metabolism
/ Glucagon
/ Homology
/ Hormones
/ Humanities and Social Sciences
/ Humans
/ Insect Hormones - metabolism
/ Insects
/ Lipids
/ Organs
/ Pyrrolidonecarboxylic Acid - analogs & derivatives
/ Pyrrolidonecarboxylic Acid - metabolism
/ Receptors, G-Protein-Coupled - genetics
/ Receptors, G-Protein-Coupled - metabolism
/ Science
