Journal Article

COLONOMICS - integrative omics data of one hundred paired normal-tumoral samples from colon cancer patients

Lopez-Doriga, Adriana, Biondo, Sebastiano, Carreras-Torres, Robert, Cordero, David, Paré-Brunet, Laia, Sanjuan, Xavier, Solé, Xavier, Closa, Adria, Moratalla-Navarro, Ferran, Diez-Obrero, Virginia, Crous-Bou, Marta, Díez-Villanueva, Anna, Aussó, Susanna, Salazar, Ramon, Alonso, Maria Henar, Moreno, Víctor, Garcia-Serrano, Ainhoa, Guinó, Elisabet, Santos, Cristina, Sanz-Pamplona, Rebeca, Berenguer, Antoni, Obón-Santacana, Mireia

2022

Overview

Colonomics is a multi-omics dataset that includes 250 samples: 50 samples from healthy colon mucosa donors and 100 paired samples from colon cancer patients (tumor/adjacent). From these samples, Colonomics project includes data from genotyping, DNA methylation, gene expression, whole exome sequencing and micro-RNAs (miRNAs) expression. It also includes data from copy number variation (CNV) from tumoral samples. In addition, clinical data from all these samples is available. The aims of the project were to explore and integrate these datasets to describe colon cancer at molecular level and to compare normal and tumoral tissues. Also, to improve screening by finding biomarkers for the diagnosis and prognosis of colon cancer. This project has its own website including four browsers allowing users to explore Colonomics datasets. Since generated data could be reuse for the scientific community for exploratory or validation purposes, here we describe omics datasets included in the Colonomics project as well as results from multi-omics layers integration. Measurement(s) Colon Gene expression • Colon DNA methylation • Colon Genptyping data • Colon Copy Number Variation • Colon miRNAs • Colon Whole Exome Sequencing Technology Type(s) Affymetrix Human Genome U219 Array Plate platform • Illumina Infinium HumanMethylation 450k BeadChip • Affymetrix Genome-Wide Human SNP 6.0 array • Small RNA Assay of the Agilent 2100 Bioanalyzer • Agilent kit Sure Select XT Human All Exon 50MB Factor Type(s) batch • background Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment colonic mucosa Sample Characteristic - Location Catalonia Autonomous Community, Spain

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 692/53 / 692/699/67/1504/1885/1393 / 692/699/67/69 / Biomarkers / Colon cancer / Colonic Neoplasms - genetics / Colorectal cancer / Copy number / Data Descriptor / Datasets / DNA Copy Number Variations / DNA methylation / Gene expression / Genomes / Genotyping / Humanities and Social Sciences / Humans / MicroRNAs / Mucosa / multidisciplinary / Patients / Prognosis / Science / Science (multidisciplinary) / Single-nucleotide polymorphism / Tumors