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Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
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Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
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Journal Article
Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
2017
Overview
The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an
in vivo
environment. Here we show a light-based dendritic cell (DC) activation allowing spatial and temporal control of immune activation
in vivo
. Additionally, we show time dependent changes in RNA profiles of the draining lymph node, suggesting a change in cell profile following DC migration and indicating that the cells migrating have been activated towards antigen presentation.
