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Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
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Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
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Journal Article
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
2021
Overview
Mycobacterium kansasii
can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the
M. kansasii
complex (MKC). Here, we report a population genomics analysis of 358 MKC isolates from worldwide water and clinical sources. We find that recombination, likely mediated by distributive conjugative transfer, has contributed to speciation and on-going diversification of the MKC. Our analyses support municipal water as a main source of MKC infections. Furthermore, nearly 80% of the MKC infections are due to closely-related
M. kansasii
strains, forming a main cluster that apparently originated in the 1900s and subsequently expanded globally. Bioinformatic analyses indicate that several genes involved in metabolism (e.g., maintenance of the methylcitrate cycle), ESX-I secretion, metal ion homeostasis and cell surface remodelling may have contributed to
M. kansasii
’s success and its ongoing adaptation to the human host.
Mycobacterium kansasii
can cause serious pulmonary disease. Here, the authors present a population genomics analysis of 358 environmental and clinical isolates from around the world, supporting the idea that municipal water is a main source of infection, and shedding light into the pathogen’s diversity and adaptation to the human host.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Drinking Water - microbiology
/ Energy Metabolism - genetics
/ Genetic Variation - genetics
/ Genetics, Population - methods
/ Genome, Bacterial - genetics
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Lung Diseases - epidemiology
/ Lung Diseases - microbiology
/ Mycobacterium Infections, Nontuberculous - epidemiology
/ Mycobacterium Infections, Nontuberculous - microbiology
/ Mycobacterium kansasii - genetics
/ Mycobacterium kansasii - isolation & purification
/ Science
