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Myocardial infarction risk is increased by periodontal pathobionts: a cross-sectional study
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Myocardial infarction risk is increased by periodontal pathobionts: a cross-sectional study
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Journal Article
Myocardial infarction risk is increased by periodontal pathobionts: a cross-sectional study
2022
Overview
To establish the role of periodontal pathobionts as a risk factor for myocardial infarction, we examined the contribution of five periodontal pathobionts and their virulence genes’ expressions to myocardial injury (Troponin-I) and coronary artery disease burden (SYNTAX-I scores) using hierarchical linear regression. Pathobiont loads in subgingival-plaques and intra-coronary-thrombi were compared. Troponin-I release increased with one 16S rRNA gene copy/ng DNA of
Porphyromonas gingivalis
(β = 6.8 × 10
–6
, 95% CI = 1.1 × 10
–7
–2.1 × 10
–5
), one-fold increased expressions of
fimA
(β = 14.3, 95% CI = 1.5–27.1),
bioF-3
(β = 7.8, 95% CI = 1.1–12.3),
prtH
(β = 1107.8, 95% CI = 235.6–2451.3),
prtP
(β = 6772.8, 95% CI = 2418.7–11,126.9),
ltxA
(β = 1811.8, 95% CI = 217.1–3840.8),
cdtB
(β = 568.3, 95% CI = 113.4–1250.1), all
p
< 0.05. SYNTAX-I score increased with one 16S rRNA gene copy/ng DNA of
Porphyromonas gingivalis
(β = 3.8 × 10
–9
, 95% CI = 3.6 × 10
–10
-1.8 × 10
–8
), one-fold increased expressions of
fimA
(β = 1.2, 95% CI = 1.1–2.1),
bioF-3
(β = 1.1, 95% CI = 1–5.2),
prtP
(β = 3, 95% CI = 1.3–4.6),
ltxA
(β = 1.5, 95% CI = 1.2–2.5), all
p
< 0.05. Within-subject
Porphyromonas gingivalis
and
Tannerella forsythia
from intra-coronary-thrombi and subgingival-plaques correlated (rho = 0.6,
p
< 0.05). Higher pathobiont load and/or upregulated virulence are risk factors for myocardial infarction.
Trial registration:
ClinicalTrials.gov Identifier: NCT04719026.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
