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Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

by Greenhouse, Jack , Brown, Renita , Fomsgaard, Anders , Cook, Anthony , Lassaunière, Ria , Andersen, Hanne , Lewis, Mark G. , Tingstedt, Jeanette Linnea , Polacek, Charlotta , Pessaint, Laurent , Putmon-Taylor, Tammy , Gram, Gregers J. , Frische, Anders , Orekov, Tatyana , Krüger, Maren , Campbell, Tracey-Ann , Dorner, Brigitte G.

in 631/250/590/1991 / 631/326/596/4130 / 631/61/24/590/1991 / Biomedical and Life Sciences / Biomedicine / COVID-19 / COVID-19 vaccines / Deoxyribonucleic acid / DNA / Immunization / Immunogenicity / Infectious Diseases / Medical Microbiology / Public Health / Severe acute respiratory syndrome coronavirus 2 / Vaccine / Vaccines / Virology

2021

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Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

2021

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Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

2021

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Journal Article

Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2

Greenhouse, Jack,

Brown, Renita,

Fomsgaard, Anders,

Cook, Anthony,

Lassaunière, Ria,

Andersen, Hanne,

Lewis, Mark G.,

Tingstedt, Jeanette Linnea,

Polacek, Charlotta,

Pessaint, Laurent,

Putmon-Taylor, Tammy,

Gram, Gregers J.,

Frische, Anders,

Orekov, Tatyana,

Krüger, Maren,

Campbell, Tracey-Ann,

Dorner, Brigitte G.

2021

Overview

New generation plasmid DNA vaccines may be a safe, fast and simple emergency vaccine platform for preparedness against emerging viral pathogens. Applying platform optimization strategies, we tested the pre-clinical immunogenicity and protective effect of a candidate DNA plasmid vaccine specific for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The DNA vaccine induced spike-specific binding IgG and neutralizing antibodies in mice, rabbits, and rhesus macaques together with robust Th1 dominant cellular responses in small animals. Intradermal and intramuscular needle-free administration of the DNA vaccine yielded comparable immune responses. In a vaccination-challenge study of rhesus macaques, the vaccine demonstrated protection from viral replication in the lungs following intranasal and intratracheal inoculation with SARS-CoV-2. In conclusion, the candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/250/590/1991

/ 631/326/596/4130

/ 631/61/24/590/1991

/ Biomedical and Life Sciences

/ Biomedicine

/ COVID-19

/ COVID-19 vaccines