Journal Article

The role of RNA modification in urological cancers: mechanisms and clinical potential

Yan, Zhaojie, zou, Junrong, Luo, Cong, Zou, Xiaofeng, Zhu, Hezhen, Zhang, Guoxi, Zhou, Xuming, Zheng, Guansong

2023

Overview

RNA modification is a post-transcriptional level of regulation that is widely distributed in all types of RNAs, including mRNA, tRNA, rRNA, miRNA, and lncRNA, where N6-methyladenine (m 6 A) is the most abundant mRNA methylation modification. Significant evidence has depicted that m 6 A modifications are closely related to human diseases, especially cancer, and play pivotal roles in RNA transcription, splicing, stabilization, and translation processes. The most common urological cancers include prostate, bladder, kidney, and testicular cancers, accounting for a certain proportion of human cancers, with an ever-increasing incidence and mortality. The recurrence, systemic metastasis, poor prognosis, and drug resistance of urologic tumors have prompted the identification of new therapeutic targets and mechanisms. Research on m 6 A modifications may provide new solutions to the current puzzles. In this review, we provide a comprehensive overview of the key roles played by RNA modifications, especially m 6 A modifications, in urologic cancers, as well as recent research advances in diagnostics and molecularly targeted therapies.

• Publisher: Springer US,Springer Nature B.V,Springer
• Subject: Biomarkers / Bladder cancer, renal cancer / Cancer Research / DNA damage / DNA methylation / Drug resistance / Epigenetics / Internal Medicine / Kidney cancer / m6A / Medical prognosis / Medicine / Medicine & Public Health / Metastasis / Molecular Medicine / Mortality / Oncology / Prostate cancer / Proteins / Radiotherapy / Review / RNA modification / Stem cells / Surgical Oncology / Testicular cancer / Transfer RNA / Tumors / Urological cancer