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Twelve or 30 Months of Dual Antiplatelet Therapy after Drug-Eluting Stents
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Journal Article
Twelve or 30 Months of Dual Antiplatelet Therapy after Drug-Eluting Stents
2014
Overview
Patients who had received a drug-eluting stent and then dual antiplatelet therapy for 12 months were randomly assigned to 18 more months of therapy or aspirin alone. Continued therapy resulted in lower rates of stent thrombosis and major adverse cardiovascular events but more bleeding.
Millions of patients worldwide undergo coronary stenting each year for the treatment of ischemic heart disease.
1
,
2
Although drug-eluting stents reduce the rate of restenosis as compared with bare-metal stents, there is concern that drug-eluting stents may be associated with a risk of stent thrombosis beyond 1 year after treatment.
3
Stent thrombosis is rare, yet it is frequently associated with myocardial infarction and may be fatal.
3
Furthermore, ischemic events, such as myocardial infarction, stroke, or death from cardiovascular causes, that are unrelated to the treated coronary lesion may also occur beyond 1 year.
4
,
5
The use of dual antiplatelet therapy . . .
Publisher
Massachusetts Medical Society
Subject
/ Aspirin
/ Aspirin - administration & dosage
/ Biological and medical sciences
/ Bleeding
/ Drug Administration Schedule
/ Female
/ Hemorrhage - chemically induced
/ Humans
/ Implants
/ Male
/ Myocardial Ischemia - epidemiology
/ Myocardial Ischemia - mortality
/ Myocardial Ischemia - therapy
/ Patients
/ Piperazines - administration & dosage
/ Piperazines - adverse effects
/ Platelet Aggregation Inhibitors - administration & dosage
/ Platelet Aggregation Inhibitors - adverse effects
/ Stents
/ Stroke
/ Thiophenes - administration & dosage
/ Thiophenes - adverse effects
/ Thrombosis - prevention & control
/ Ticlopidine - administration & dosage
/ Ticlopidine - adverse effects
