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Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy
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Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy
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Journal Article
Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy
2024
Overview
Practical photodynamic therapy calls for high-performance, less O
2
-dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O
2
-dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region. Reactive oxygen species generation of metallopolymer
Ir-P1
, where the iridium atom is covalently coupled to the polymer backbone, is over 80 times higher than that of its mother polymer without iridium under 680 nm irradiation. This strategy also works effectively when the iridium atom is directly included (
Ir-P2
) in the polymer backbones, exhibiting wide generality. The metallopolymer nanoparticles exhibiting efficient O
2
•−
generation are conjugated with integrin αvβ3 binding cRGD to achieve targeted photodynamic therapy.
Iridium-based photosensitizers exhibit good photocatalytic performance, but the in vivo applications are hindered by conventional O
2
-dependent Type-II photochemistry and poor absorption. Here, the authors report a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
