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Higher-energy C-trap dissociation for peptide modification analysis
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Journal Article
Higher-energy C-trap dissociation for peptide modification analysis
2007
Overview
Peptide sequencing is the basis of mass spectrometry–driven proteomics. Here we show that in the linear ion trap–orbitrap mass spectrometer (LTQ Orbitrap) peptide ions can be efficiently fragmented by high-accuracy and full-mass-range tandem mass spectrometry (MS/MS) via higher-energy C-trap dissociation (HCD). Immonium ions generated via HCD pinpoint modifications such as phosphotyrosine with very high confidence. Additionally we show that an added octopole collision cell facilitates
de novo
sequencing.
Publisher
Nature Publishing Group US,Nature Publishing Group
