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Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila
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Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila
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Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila
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Journal Article
Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila
2023
Overview
Neuronal cell death and subsequent brain dysfunction are hallmarks of aging and neurodegeneration, but how the nearby healthy neurons (bystanders) respond to the death of their neighbors is not fully understood. In the
Drosophila
larval neuromuscular system, bystander motor neurons can structurally and functionally compensate for the loss of their neighbors by increasing their terminal bouton number and activity. We term this compensation as cross-neuron plasticity, and in this study, we demonstrate that the
Drosophila
engulfment receptor, Draper, and the associated kinase, Shark, are required for cross-neuron plasticity. Overexpression of the Draper-I isoform boosts cross-neuron plasticity, implying that the strength of plasticity correlates with Draper signaling. In addition, we find that functional cross-neuron plasticity can be induced at different developmental stages. Our work uncovers a role for Draper signaling in cross-neuron plasticity and provides insights into how healthy bystander neurons respond to the loss of their neighboring neurons.
Neuronal death is a feature of development and neurodegeneration. Here, the authors report that ablation of
Drosophila
motor neurons triggers Draper-dependent signaling in glia to engage ‘cross-neuron plasticity’ in bystander neurons.
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