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Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer
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Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer
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Journal Article
Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer
2023
Overview
Helicobacter pylori
(
H. pylori
) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role in pathophysiology of gastric cancer. The aim of the study was to explore the link between gastric cancer prognosis and the mucosal microbial community in tumorous and adjacent gastric tissue. The bacterial profile was analysed using 16S sequencing (V1–V2 region). Microbial differences were mostly characterized by lower relative abundances of
H. pylori
in tumorous gastric tissues. Bacterial community and outcome data analysis revealed the genus
Fusobacterium
and
Prevotella
significantly associated with worse overall survival in gastric cancer patients. In particular,
Fusobacterium
was associated with significant increase in hazard ratio in both univariable and multivariable analysis and independently validated using TCMA data. Phylogenetic biodiversity of
Fusobacterium
species in the stomach revealed
F. periodonticum
as the most prevalent in healthy subjects, while
F. nucleatum
was most abundant in patients with gastric cancer. Bacterial community network analysis in gastric cancer suggests substantial complexity and a strong interplay between
F. nucleatum
and
Prevotella.
In summary, mucosal microbial community in the stomach was associated with worse overall survival in gastric cancer patients. Strongest negative impact on prognosis was linked to the abundance of
F. nucleatum
in tumorous specimens, suggesting its translational relevance in management of gastric cancer patients.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
