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International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe
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International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe
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Journal Article
International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe
2024
Overview
Carbapenem-resistant
Klebsiella pneumoniae
(CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307.
bla
KPC-like
was the most prevalent carbapenemase-encoding gene (46%), with
bla
OXA-48
present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found
bla
KPC-like
ST258/512 in Greece, Italy, and Spain,
bla
OXA-48
ST101 in Serbia and Romania,
bla
NDM
ST11 in Greece, and
bla
OXA-48-like
ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.
Klebsiella pneumoniae
is an opportunistic pathogen of increasing concern due to the spread of carbapenem resistance. In this study, the authors sequence carbapenem-resistant strains from a hospital surveillance network in southern Europe, describe evolution of high-risk clones, and identify locally important lineages.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ 631/114
/ 631/326
/ Anti-Bacterial Agents - pharmacology
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ beta-Lactamases - metabolism
/ Carbapenem-Resistant Enterobacteriaceae - drug effects
/ Carbapenem-Resistant Enterobacteriaceae - genetics
/ Carbapenem-Resistant Enterobacteriaceae - isolation & purification
/ Cloning
/ Humanities and Social Sciences
/ Humans
/ Klebsiella Infections - epidemiology
/ Klebsiella Infections - microbiology
/ Klebsiella pneumoniae - drug effects
/ Klebsiella pneumoniae - genetics
/ Klebsiella pneumoniae - isolation & purification
/ Risk
/ Science
