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Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance
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Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance
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Journal Article
Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance
2024
Overview
Heat stress (HS) poses a significant challenge to plant survival, necessitating sophisticated molecular mechanisms to maintain cellular homeostasis. Here, we identify SICKLE (SIC) as a key modulator of HS responses in Arabidopsis (
Arabidopsis thaliana
). SIC is required for the sequestration of RNA DEBRANCHING ENZYME 1 (DBR1), a rate-limiting enzyme of lariat intronic RNA (lariRNA) decay, into stress granules (SGs). The sequestration of DBR1 by SIC enhances the accumulation of lariRNAs, branched circular RNAs derived from excised introns during pre-mRNA splicing, which in turn promote the transcription of their parental genes. Our findings further demonstrate that SIC-mediated DBR1 sequestration in SGs is crucial for plant HS tolerance, as deletion of the N-terminus of SIC (SIC
1–244
) impairs DBR1 sequestration and compromises plant response to HS. Overall, our study unveils a mechanism of transcriptional regulation in the HS response, where lariRNAs are enriched through DBR1 sequestration, ultimately promoting the transcription of heat stress tolerance genes.
SICKLE sequestrates DBR1 into stress granules to promote the accumulation of lariRNAs, which upregulate heat stress-related genes and enhance heat-stress tolerance.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/32
/ 42/35
/ 45/91
/ 49/15
/ 49/39
/ 49/88
/ 49/90
/ 82/1
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Enzymes
/ Gene Expression Regulation, Plant
/ Genes
/ Heat-Shock Response - genetics
/ Humanities and Social Sciences
/ Introns
/ Plants, Genetically Modified
/ RNA
/ Science
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