Journal Article

Cardiovascular autonomic alterations in hospitalized patients with community-acquired pneumonia

Casazza, Giovanni, D’Adda, Alice, Queiroz, Andreia, Bonaiti, Giulia, Suigo, Giulia, Montano, Nicola, Roveda, Andrea, Monzani, Valter, Giuliani, Fabio, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Pesci, Alberto, Nunziata, Vanessa

2016

Overview

Background Alterations of cardiac autonomic control (CAC) are associated with poor outcomes in patients with infectious and non-infectious diseases. No evaluation of CAC in patients with community-acquired pneumonia (CAP) has been performed so far. The aim of the study was to assess CAC in patients with CAP and evaluate the impact of its alterations on disease severity and clinical outcomes in a multicenter, prospective, observational study. Methods Consecutive patients hospitalized for CAP were enrolled between 2011 and 2013 two university hospitals in Italy. CAC was assessed by linear spectral and non-linear symbolic analysis of heart rate variability. The presence of severe CAP was evaluated on hospital admission. The primary study outcome was time to clinical stability (TCS) during hospitalization. Results Among the 75 patients enrolled (median age: 75 years; 57 % males), a significantly lower total variability and reduction of sympathetic rhythmical component with predominant respiratory modulation was detected in comparison to controls. Among CAP patients affected by a severe CAP on admission, CAC showed a lower sympathetic modulation and predominant parasympathetic oscillatory rhythm. At the multivariate analysis, variables independently correlated with a TCS >7 days were total power, as marker of total variability, [OR (95 % CI): 0.997 (0.994–1.000), p  = 0.0454] and sympathetic modulation [OR (95 % CI): 0.964 (0.932–0.998), p  = 0.0367]. Conclusions Loss of sympathetic rhythmical oscillation is associated with a more severe disease and worse early clinical outcome in hospitalized patients with CAP.

• Publisher: BioMed Central,BioMed Central Ltd
• Subject: Aged / Aged, 80 and over / Antibiotics / Autonomic Nervous System - physiopathology / Bacterial pneumonia / Cardiovascular System - physiopathology / Care and treatment / Community-Acquired Infections - physiopathology / Complications and side effects / Electrocardiography / Female / Health aspects / Heart Rate / Hospital patients / Hospitalization / Humans / Length of Stay / Male / Medicine / Medicine & Public Health / Middle Aged / Pilot Projects / Pneumology/Respiratory System / Pneumonia / Pneumonia - physiopathology / Prospective Studies