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MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)
by
WU, BIN
, YIN, BO
, GUO, QIZHEN
, LI, MING
, SONG, YONGSHENG
, BU, RENGE
, WANG, YING
, FEI, XIANG
in
Adenylate Kinase - genetics
/ Adenylate Kinase - physiology
/ Apoptosis
/ Biomarkers
/ Biomarkers, Tumor
/ Cancer therapies
/ Carcinoma, Renal cell
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - drug therapy
/ Carcinoma, Renal Cell - genetics
/ Carcinoma, Renal Cell - physiopathology
/ Cell cycle
/ Cell growth
/ Chromosomal Instability
/ Development and progression
/ diagnosis
/ DNA Methylation
/ Gene expression
/ Gene Expression Regulation, Neoplastic - drug effects
/ Genetic aspects
/ Health aspects
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit - genetics
/ Hypoxia-Inducible Factor 1, alpha Subunit - physiology
/ Kidney cancer
/ Kidney Neoplasms - diagnosis
/ Kidney Neoplasms - drug therapy
/ Kidney Neoplasms - genetics
/ Kidney Neoplasms - physiopathology
/ Medical diagnosis
/ Medical prognosis
/ Metastasis
/ MicroRNA
/ MicroRNAs
/ MicroRNAs - blood
/ MicroRNAs - genetics
/ MicroRNAs - therapeutic use
/ Molecular Targeted Therapy
/ Motility
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Phosphatidylinositol 3-Kinases - genetics
/ Phosphatidylinositol 3-Kinases - physiology
/ Prognosis
/ renal cell carcinoma
/ RNA polymerase
/ RNA, Messenger - genetics
/ RNA, Neoplasm - blood
/ RNA, Neoplasm - genetics
/ RNA, Neoplasm - therapeutic use
/ Signal Transduction
/ therapy
/ Tumors
/ Von Hippel-Lindau Tumor Suppressor Protein - genetics
/ Von Hippel-Lindau Tumor Suppressor Protein - physiology
2015
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MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)
by
WU, BIN
, YIN, BO
, GUO, QIZHEN
, LI, MING
, SONG, YONGSHENG
, BU, RENGE
, WANG, YING
, FEI, XIANG
in
Adenylate Kinase - genetics
/ Adenylate Kinase - physiology
/ Apoptosis
/ Biomarkers
/ Biomarkers, Tumor
/ Cancer therapies
/ Carcinoma, Renal cell
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - drug therapy
/ Carcinoma, Renal Cell - genetics
/ Carcinoma, Renal Cell - physiopathology
/ Cell cycle
/ Cell growth
/ Chromosomal Instability
/ Development and progression
/ diagnosis
/ DNA Methylation
/ Gene expression
/ Gene Expression Regulation, Neoplastic - drug effects
/ Genetic aspects
/ Health aspects
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit - genetics
/ Hypoxia-Inducible Factor 1, alpha Subunit - physiology
/ Kidney cancer
/ Kidney Neoplasms - diagnosis
/ Kidney Neoplasms - drug therapy
/ Kidney Neoplasms - genetics
/ Kidney Neoplasms - physiopathology
/ Medical diagnosis
/ Medical prognosis
/ Metastasis
/ MicroRNA
/ MicroRNAs
/ MicroRNAs - blood
/ MicroRNAs - genetics
/ MicroRNAs - therapeutic use
/ Molecular Targeted Therapy
/ Motility
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Phosphatidylinositol 3-Kinases - genetics
/ Phosphatidylinositol 3-Kinases - physiology
/ Prognosis
/ renal cell carcinoma
/ RNA polymerase
/ RNA, Messenger - genetics
/ RNA, Neoplasm - blood
/ RNA, Neoplasm - genetics
/ RNA, Neoplasm - therapeutic use
/ Signal Transduction
/ therapy
/ Tumors
/ Von Hippel-Lindau Tumor Suppressor Protein - genetics
/ Von Hippel-Lindau Tumor Suppressor Protein - physiology
2015
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MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)
by
WU, BIN
, YIN, BO
, GUO, QIZHEN
, LI, MING
, SONG, YONGSHENG
, BU, RENGE
, WANG, YING
, FEI, XIANG
in
Adenylate Kinase - genetics
/ Adenylate Kinase - physiology
/ Apoptosis
/ Biomarkers
/ Biomarkers, Tumor
/ Cancer therapies
/ Carcinoma, Renal cell
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - drug therapy
/ Carcinoma, Renal Cell - genetics
/ Carcinoma, Renal Cell - physiopathology
/ Cell cycle
/ Cell growth
/ Chromosomal Instability
/ Development and progression
/ diagnosis
/ DNA Methylation
/ Gene expression
/ Gene Expression Regulation, Neoplastic - drug effects
/ Genetic aspects
/ Health aspects
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit - genetics
/ Hypoxia-Inducible Factor 1, alpha Subunit - physiology
/ Kidney cancer
/ Kidney Neoplasms - diagnosis
/ Kidney Neoplasms - drug therapy
/ Kidney Neoplasms - genetics
/ Kidney Neoplasms - physiopathology
/ Medical diagnosis
/ Medical prognosis
/ Metastasis
/ MicroRNA
/ MicroRNAs
/ MicroRNAs - blood
/ MicroRNAs - genetics
/ MicroRNAs - therapeutic use
/ Molecular Targeted Therapy
/ Motility
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Phosphatidylinositol 3-Kinases - genetics
/ Phosphatidylinositol 3-Kinases - physiology
/ Prognosis
/ renal cell carcinoma
/ RNA polymerase
/ RNA, Messenger - genetics
/ RNA, Neoplasm - blood
/ RNA, Neoplasm - genetics
/ RNA, Neoplasm - therapeutic use
/ Signal Transduction
/ therapy
/ Tumors
/ Von Hippel-Lindau Tumor Suppressor Protein - genetics
/ Von Hippel-Lindau Tumor Suppressor Protein - physiology
2015
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MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)
Journal Article
MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review)
2015
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Overview
Despite recent advances in the understanding of the biology of renal cell carcinoma (RCC), successful surgical treatment and implementation of novel-targeted therapies, the prognosis for RCC patients remains poor. Late presentation, tumor heterogeneity and in particular the lack of molecular biomarkers for early detection, classification and the surveillance of RCC treatments are major obstacles. The increasing knowledge regarding the functional role of microRNAs (miRNAs) in pathophysiological processes may provide an important link to the identification of suitable therapeutic targets and diagnostic/prognostic biomarkers for RCC. The aim of this review was to provide new insight into the function of miRNAs in the pathogenesis of RCC and to emphasize their potential as diagnostic and prognostic markers, as well as therapeutic targets.
Publisher
D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd
Subject
/ Adenylate Kinase - physiology
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - drug therapy
/ Carcinoma, Renal Cell - genetics
/ Carcinoma, Renal Cell - physiopathology
/ Gene Expression Regulation, Neoplastic - drug effects
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit - genetics
/ Hypoxia-Inducible Factor 1, alpha Subunit - physiology
/ Kidney Neoplasms - diagnosis
/ Kidney Neoplasms - drug therapy
/ Kidney Neoplasms - physiopathology
/ MicroRNA
/ Motility
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Phosphatidylinositol 3-Kinases - genetics
/ Phosphatidylinositol 3-Kinases - physiology
/ RNA, Neoplasm - therapeutic use
/ therapy
/ Tumors
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