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RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening
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RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening
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Journal Article
RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening
2024
Overview
Telomere shortening is a prominent hallmark of aging and is emerging as a characteristic feature of Myelodysplastic Syndromes (MDS) and Idiopathic Pulmonary Fibrosis (IPF). Optimal telomerase activity prevents progressive shortening of telomeres that triggers DNA damage responses. However, the upstream regulation of telomerase holoenzyme components remains poorly defined. Here, we identify RIOK2, a master regulator of human blood cell development, as a critical transcription factor for telomere maintenance. Mechanistically, loss of RIOK2 or its DNA-binding/transactivation properties downregulates mRNA expression of both TRiC and dyskerin complex subunits that impairs telomerase activity, thereby causing telomere shortening. We further show that
RIOK2
expression is diminished in aged individuals and IPF patients, and it strongly correlates with shortened telomeres in MDS patient-derived bone marrow cells. Importantly, ectopic expression of RIOK2 alleviates telomere shortening in IPF patient-derived primary lung fibroblasts. Hence, increasing RIOK2 levels prevents telomere shortening, thus offering therapeutic strategies for telomere biology disorders.
Telomere shortening is a hallmark of several disorders and aging. Here, the authors uncover that RIOK2 maintains telomerase activity, thereby preventing telomere shortening. Thus, increasing RIOK2 levels may help rescue telomere biology disorders.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/106
/ 13/109
/ 14
/ 14/1
/ 14/32
/ 14/63
/ 38
/ 38/15
/ Aging
/ Biology
/ Cell Cycle Proteins - genetics
/ Cell Cycle Proteins - metabolism
/ DNA
/ Fibrosis
/ Humanities and Social Sciences
/ Humans
/ Idiopathic Pulmonary Fibrosis - genetics
/ Idiopathic Pulmonary Fibrosis - metabolism
/ Idiopathic Pulmonary Fibrosis - pathology
/ Myelodysplastic Syndromes - genetics
/ Myelodysplastic Syndromes - metabolism
/ Nuclear Proteins - metabolism
/ Science
/ Yeast
