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Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
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Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
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Journal Article
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
2017
Overview
Long noncoding RNAs contribute to the cell-type-specific regulation of gene expression. Fan and colleagues identify a unique conserved lncRNA,
lncKdm2b
, that is transcribed divergently from the
Kdm2b
gene and is necessary for ILC3 maintenance in the gut.
Innate lymphoid cells (ILCs) communicate with other hematopoietic and nonhematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How ILC lineages develop and are maintained remains largely unknown. In this study we observed that a divergent long noncoding RNA (lncRNA),
lncKdm2b
, was expressed at high levels in intestinal group 3 ILCs (ILC3s).
LncKdm2b
deficiency in the hematopoietic system led to reductions in the number and effector functions of ILC3s.
LncKdm2b
expression sustained the maintenance of ILC3s by promoting their proliferation through activation of the transcription factor Zfp292. Mechanistically,
lncKdm2b
recruited the chromatin organizer Satb1 and the nuclear remodeling factor (NURF) complex onto the
Zfp292
promoter to initiate its transcription. Deletion of
Zfp292
or
Bptf
also abrogated the maintenance of ILC3s, leading to susceptibility to bacterial infection. Therefore, our findings reveal that lncRNAs may represent an additional layer of regulation of ILC development and function.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/32
/ 38/39
/ 38/61
/ 45/90
/ Animals
/ Antigens, Nuclear - genetics
/ Bacterial Infections - genetics
/ Cell Differentiation - genetics
/ Cell Proliferation - genetics
/ Chromatin Assembly and Disassembly
/ DNA-Binding Proteins - genetics
/ Jumonji Domain-Containing Histone Demethylases - genetics
/ Matrix Attachment Region Binding Proteins - genetics
/ Mice
/ Nerve Tissue Proteins - genetics
/ RNA
/ RNA, Long Noncoding - genetics
