Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice

by Plante, Obadiah , Damron, F. Heath , Bevere, Justin R. , Deal, Cailin E. , Hall, Jesse M. , Falcone, Samantha , Richards, Angelene , Carfi, Andrea , Ogega, Clinton , Russo, Lisa , Narayanan, Elisabeth , King, Emily , O’Hara, Joanne M. , Nguyen, Brenda , Wolf, M. Allison , DeJong, Megan A. , Barbier, Mariette , Boehm, Dylan T. , Sen-Kilic, Emel , Bitzer, Graham J. , Himansu, Sunny , Wong, Ting Y. , Green, Shannon

in 631/250/590/2293 / 631/326/590/2293 / Bacterial diseases / Biomedical and Life Sciences / Biomedicine / Immunization / Immunogenicity / Infant mortality / Infectious Diseases / Medical Microbiology / Public Health / Toxins / Vaccine / Vaccines / Virology / Whooping cough

2024

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice

2024

Confirm

Do you wish to request the book?

Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice

2024

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice

Plante, Obadiah,

Damron, F. Heath,

Bevere, Justin R.,

Deal, Cailin E.,

Hall, Jesse M.,

Falcone, Samantha,

Richards, Angelene,

Carfi, Andrea,

Ogega, Clinton,

Russo, Lisa,

Narayanan, Elisabeth,

King, Emily,

O’Hara, Joanne M.,

Nguyen, Brenda,

Wolf, M. Allison,

DeJong, Megan A.,

Barbier, Mariette,

Boehm, Dylan T.,

Sen-Kilic, Emel,

Bitzer, Graham J.,

Himansu, Sunny,

Wong, Ting Y.,

Green, Shannon

2024

Overview

Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over time resulting in cyclic epidemics of pertussis. The messenger RNA (mRNA) vaccine platform provides an opportunity to address complex bacterial infections with an adaptable approach providing Th1-biased responses. In this study, immunogenicity and challenge models were used to evaluate the mRNA platform with multivalent vaccine formulations targeting both B. pertussis antigens and diphtheria and tetanus toxoids. Immunization with mRNA formulations were immunogenetic, induced antigen specific antibodies, as well as Th1 T cell responses. Upon challenge with either historical or contemporary B. pertussis strains, 6 and 10 valent mRNA DTP vaccine provided protection equal to that of 1/20th human doses of either DTaP or whole cell pertussis vaccines. mRNA DTP immunized mice were also protected from pertussis toxin challenge as measured by prevention of lymphocytosis and leukocytosis. Collectively these pre-clinical mouse studies illustrate the potential of the mRNA platform for multivalent bacterial pathogen vaccines.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/250/590/2293

/ 631/326/590/2293

/ Bacterial diseases

/ Biomedical and Life Sciences

/ Biomedicine

/ Immunization

/ Immunogenicity