Asset Details
Do you wish to reserve the book?
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
Do you wish to request the book?
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance
2024
Overview
Tissue regeneration is a complex process involving large changes in cell proliferation, fate determination, and differentiation. Mitochondrial dynamics and metabolism play a crucial role in development and wound repair, but their function in large-scale regeneration remains poorly understood. Planarians offer an excellent model to investigate this process due to their remarkable regenerative abilities. In this study, we examine mitochondrial dynamics during planarian regeneration. We find that knockdown of the mitochondrial fusion gene,
opa1
, impairs both tissue regeneration and stem cell pluripotency. Interestingly, the regeneration defects caused by
opa1
knockdown are rescued by simultaneous knockdown of the mitochondrial fission gene,
drp1
, which partially restores mitochondrial dynamics. Furthermore, we discover that Mito
low
stem cells exhibit an enrichment of pluripotency due to their fate choices at earlier stages. Transcriptomic analysis reveals the delicate mitonuclear balance in metabolism and mitochondrial proteins in regeneration, controlled by mitochondrial dynamics. These findings highlight the importance of maintaining mitochondrial dynamics in large-scale tissue regeneration and suggest the potential for manipulating these dynamics to enhance stem cell functionality and regenerative processes.
Mitochondrial dynamics in large-scale regeneration remain poorly understood. Here they show that the mitochondrial fusion-fission equilibrium can determine the pluripotency of planarian stem cells and that mitonuclear balance is critical for planarian regeneration.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/100
/ 13/106
/ 13/109
/ 13/31
/ 13/89
/ 14/19
/ 14/28
/ 14/32
/ 38/91
/ 49/88
/ Animals
/ Dynamics
/ Fission
/ Humanities and Social Sciences
/ Mitochondrial Proteins - genetics
/ Mitochondrial Proteins - metabolism
/ Pluripotent Stem Cells - cytology
/ Pluripotent Stem Cells - metabolism
/ Science
