Journal Article

Probability of Cancer in Pulmonary Nodules Detected on First Screening CT

Soghrati, Kam, Stewart, Lori, Bhatia, Rick, Burrowes, Paul, Tammemagi, Martin C, Roberts, Heidi, Puksa, Serge, Goss, Glenwood D, MacEachern, Paul, English, John, McWilliams, Annette, Lam, Stephen, Berg, Christine D, Tsao, Ming-Sound, Tsai, Scott, Mayo, John R, Gingras, Michel, Johnston, Michael R, Martel, Simon, Evans, Ken, Amjadi, Kayvan, Yee, John, Manos, Daria, Nicholas, Garth, Atkar-Khattra, Sukhinder, Finley, Richard, Tremblay, Alain, Liu, Geoffrey, Goffin, John, Seely, Jean M, Laberge, Francis, Yasufuku, Kazuhiro, Nasute, Paola

2013

Overview

Using data from two large data sets of lung-cancer screening by CT, the authors identified factors that increased the likelihood that a nodule was malignant, including older age, female sex, nodule location in the upper lobe, lower nodule count, and certain nodule features. The U.S. National Lung Screening Trial showed that screening with the use of low-dose thoracic computed tomography (CT) reduces mortality from lung cancer by 20%. 1 Major clinical issues in the implementation of low-dose CT screening at the population level include the definition of a positive screening result and the appropriate management of lung nodules detected on a scan. More than 20% of participants in low-dose CT screening programs were found on their first scan to have one or more lung nodules that required further investigation. 1 – 4 The proportion of invasive diagnostic procedures ranged from 1 to 4%. 1 , 3 The risk . . .

• Publisher: Massachusetts Medical Society
• Subject: Biological and medical sciences / Clinical trials / Computed tomography / Data processing / Emphysema / Evidence-Based Medicine / Female / Follow-Up Studies / General aspects / Humans / Logistic Models / Lung - diagnostic imaging / Lung - pathology / Lung cancer / Lung Neoplasms - diagnostic imaging / Lung Neoplasms - pathology / Lung nodules / Male / Medical imaging / Medical research / Medical sciences / Medical screening / Models, Statistical / Multiple Pulmonary Nodules - diagnostic imaging / Multiple Pulmonary Nodules - pathology / Multiple tumors. Solid tumors. Tumors in childhood (general aspects) / Pneumology / Population studies / Probability / Prospective Studies / Regression analysis / Solitary Pulmonary Nodule - diagnostic imaging / Solitary Pulmonary Nodule - pathology / Tomography, X-Ray Computed / Tumors / Tumors of the respiratory system and mediastinum