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Fibulin-3 as a Blood and Effusion Biomarker for Pleural Mesothelioma
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Fibulin-3 as a Blood and Effusion Biomarker for Pleural Mesothelioma
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Journal Article
Fibulin-3 as a Blood and Effusion Biomarker for Pleural Mesothelioma
2012
Overview
Plasma levels of fibulin-3 reliably distinguish patients with pleural mesothelioma from patients with other types of pleural effusions and asbestos-exposed persons.
Despite advances in chemotherapy, radiation therapy, and surgical management for malignant pleural mesothelioma, the median survival remains 12 months.
1
Early detection is limited by the long latency period, an inability of imaging to detect the disease at an early stage even when it is used as a screening strategy, and the lack of sensitive and specific blood-based markers.
2
Moreover, in patients with undiagnosed pleural effusion, the ability to diagnose mesothelioma is delayed by failure to include the disease in the differential diagnosis and by the lack of noninvasive mesothelioma-specific blood-based markers. Soluble mesothelin-related protein, the most extensively studied blood-based mesothelioma . . .
Publisher
Massachusetts Medical Society
Subject
/ Asbestos
/ Benign
/ Biological and medical sciences
/ Cancer
/ Effusion
/ Enzyme-linked immunosorbent assay
/ Extracellular Matrix Proteins - blood
/ Female
/ Humans
/ Male
/ Patients
/ Plasma
/ Pleural Effusion - diagnosis
/ Pleural Effusion, Malignant - blood
/ Pleural Effusion, Malignant - diagnosis
