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A Field Trial to Assess a Blood-Stage Malaria Vaccine

by Sissoko, Mahamadou S , Lyke, Kirsten E , Ouattara, Amed , Coulibaly, Drissa , Dolo, Amagana , Heppner, D. Gray , House, Brent , Traore, Idrissa , Godeaux, Olivier , Kouriba, Bourema , Soisson, Lorraine , Sissoko, Mady , Dutta, Sheetij , Diarra, Issa , Takala-Harrison, Shannon , Thompson, Darby , Diallo, Dapa A , Vekemans, Johan , Doumbo, Ogobara K , Dube, Tina , Cohen, Joe , Kone, Abdoulaye K , Wu, Yukun , Laurens, Matthew B , Traore, Karim , Guindo, Ando B , Daou, Modibo , Lanar, David E , Plowe, Christopher V , Ballou, W. Ripley , Blackwelder, William C , Thera, Mahamadou A , Dubois, Marie-Claude , Niangaly, Amadou , Diggs, Carter L , Tolo, Youssouf

in Allergies / Antibodies, Protozoan - blood / Antigens, Protozoan - immunology / Apical membrane antigen 1 / Armed forces / Biological and medical sciences / Biological anthropology / Blood / Child, Preschool / Children / Clinical trials / Double-Blind Method / Female / Fever / General aspects / Human health and pathology / Human protozoal diseases / Humanities and Social Sciences / Humans / Immunization / Immunogenicity / Immunology / Infectious diseases / Kaplan-Meier Estimate / Life Sciences / Malaria / Malaria Vaccines - adverse effects / Malaria Vaccines - immunology / Malaria, Falciparum - parasitology / Malaria, Falciparum - prevention & control / Male / Medical sciences / Membrane proteins / Nucleotide sequence / Parasites / Parasitic diseases / Plasmodium falciparum / Plasmodium falciparum - immunology / Plasmodium falciparum - isolation & purification / Prevention and actions / Proportional Hazards Models / Protozoal diseases / Public health. Hygiene / Public health. Hygiene-occupational medicine / Rabies / Rabies Vaccines / Vaccines / Vaccinology

2011

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A Field Trial to Assess a Blood-Stage Malaria Vaccine

2011

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2011

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Journal Article

A Field Trial to Assess a Blood-Stage Malaria Vaccine

Sissoko, Mahamadou S,

Lyke, Kirsten E,

Ouattara, Amed,

Coulibaly, Drissa,

Dolo, Amagana,

Heppner, D. Gray,

House, Brent,

Traore, Idrissa,

Godeaux, Olivier,

Kouriba, Bourema,

Soisson, Lorraine,

Sissoko, Mady,

Dutta, Sheetij,

Diarra, Issa,

Takala-Harrison, Shannon,

Thompson, Darby,

Diallo, Dapa A,

Vekemans, Johan,

Doumbo, Ogobara K,

Dube, Tina,

Cohen, Joe,

Kone, Abdoulaye K,

Wu, Yukun,

Laurens, Matthew B,

Traore, Karim,

Guindo, Ando B,

Daou, Modibo,

Lanar, David E,

Plowe, Christopher V,

Ballou, W. Ripley,

Blackwelder, William C,

Thera, Mahamadou A,

Dubois, Marie-Claude,

Niangaly, Amadou,

Diggs, Carter L,

Tolo, Youssouf

2011

Overview

In this study of 400 children in Mali, an adjuvanted vaccine based on an apical membrane antigen 1 from the 3D7 strain of Plasmodium falciparum (a blood-stage antigen) showed some strain-specific activity in preventing clinical malaria. An effective malaria vaccine would improve the prospects for eradicating malaria. 1 Vaccines that interrupt the transmission of malaria are emphasized in discussions of eradication, 2 but the ideal malaria vaccine would provide a direct clinical benefit. Vaccines targeting the blood stages of malaria are intended to reduce morbidity and mortality and are being developed in hopes of creating a multistage, multiantigen vaccine. 3 Vaccines based on two polymorphic Plasmodium falciparum blood-stage proteins, merozoite surface protein 1 4 and apical membrane antigen 1 (AMA1), 5 were not shown to be effective in recent studies, probably because of insufficient cross-protection against diverse malaria strains 6 , 7 or . . .

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Publisher

Massachusetts Medical Society

Subject

Allergies

/ Antibodies, Protozoan - blood

/ Antigens, Protozoan - immunology

/ Apical membrane antigen 1

/ Armed forces

/ Biological and medical sciences

/ Biological anthropology