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A Controlled Trial of Artemether or Quinine in Vietnamese Adults with Severe Falciparum Malaria
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A Controlled Trial of Artemether or Quinine in Vietnamese Adults with Severe Falciparum Malaria
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Journal Article
A Controlled Trial of Artemether or Quinine in Vietnamese Adults with Severe Falciparum Malaria
1996
Overview
Since the cinchona alkaloids were introduced as a specific treatment for agues 350 years ago, the treatment of severe malaria has changed little. Quinine and quinidine remain the drugs of choice for severe chloroquine-resistant malaria due to
Plasmodium falciparum,
and with the spread of these resistant parasites, the usage of these drugs is increasing.
1
In 1972 scientists in China discovered the antimalarial properties of a group of sesquiterpene lactone peroxides derived from the qinghao plant (
Artemisia
annua
).
2
The principal component, qinghaosu (artemisinin), and two derivatives — the water-soluble hemisuccinate artesunate and the oil-soluble artemether — are the most . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Aged
/ Animals
/ Antimalarials - adverse effects
/ Antimalarials - therapeutic use
/ Biological and medical sciences
/ Clinical trial. Drug monitoring
/ Female
/ Humans
/ Malaria
/ Malaria, Falciparum - drug therapy
/ Malaria, Falciparum - mortality
/ Male
/ Patients
/ Pharmacology. Drug treatments
/ Plasmodium falciparum - isolation & purification
/ Sesquiterpenes - adverse effects
