Journal Article

Intravenous Prostaglandin E1 Infusion for Acute Central Retinal Artery Occlusion

Lin, Xihui, Padidam, Sneha, Burke, Marie, Mishulin, Aleksey, Malbin, Brett, Akhter, Mashal, Eby, Alicia

2019

Overview

BACKGROUND AND OBJECTIVE:To evaluate the efficacy of systemic prostaglandin E1 (PGE1) infusion within the first 24 hours of acute central retinal artery occlusion (CRAO). PATIENTS AND METHODS:Best corrected visual acuity (BCVA) was analyzed in a case series of six eyes from six patients (mean age: 69.33 years) with acute CRAO who were treated with twice-daily intravenous infusion of 40 μg PGE1. Therapy continued until the patient no longer experienced visual acuity improvements for 24 hours. RESULTS:Average time to presentation was 8.33 hours (range: 2 to 12 hours). The logMAR BCVA at presentation was 2.73. BCVA at the final visit 1 month after initial presentation was 1.48 (P = .025). All patients experienced vision improvement. No systemic adverse events were experienced. CONCLUSION:Intravenous PGE1 infusion resulted in significant visual improvement in patients presenting with acute CRAO and is well tolerated with few adverse effects.[Ophthalmic Surg Lasers Imaging Retina. 2019;50:S5–S8.]

• Publisher: SLACK Incorporated,Slack, Inc,SLACK INCORPORATED
• Subject: African Americans / Age / Aged / Aged, 80 and over / Alprostadil - administration & dosage / Care and treatment / Dose-Response Relationship, Drug / Eye (anatomy) / Female / Flow velocity / Fluorescein Angiography / Follow-Up Studies / Fundus Oculi / Humans / Infusions, Intravenous / Intravenous infusion / Ischemia / Male / Middle Aged / Natural history / Occlusion / Patients / Prostaglandins E / Regression analysis / Retina / Retina - pathology / Retinal Artery Occlusion - diagnosis / Retinal Artery Occlusion - drug therapy / Retinal diseases / Retrospective Studies / Treatment Outcome / Vasodilator Agents - administration & dosage / Veins & arteries / Visual Acuity