Asset Details
Do you wish to reserve the book?
Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice
Do you wish to request the book?
Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice
2017
Overview
The success of subunit vaccines has been hampered by the problems of weak or short-term immunity and the lack of availability of nontoxic, potent adjuvants. It would be desirable to develop safe and efficient adjuvants with the aim of improving the cellular immune response against the target antigen. In this study, the targeting and sustained release of simple nanoliposomes containing
polysaccharides (LBP) as an efficacious immune adjuvant to improve immune responses were explored. LBP liposome (LBPL) with high entrapment efficiency (86%) were obtained using a reverse-phase evaporation method and then used to encapsulate the model antigen, ovalbumin (OVA). We demonstrated that the as-synthesized liposome loaded with OVA and LBP (LBPL-OVA) was stable for 45 days and determined the encapsulation stability of OVA at 4°C and 37°C and the release profile of OVA from LBPL-OVA was investigated in pH 7.4 and pH 5.0. Further in vivo investigation showed that the antigen-specific humoral response was correlated with antigen delivery to the draining lymph nodes. The LBPL-OVA were also associated with high levels of uptake by key dendritic cells in the draining lymph nodes and they efficiently stimulated CD4
and CD8
T cell proliferation in vivo, further promoting antibody production. These features together elicited a significant humoral and celluar immune response, which was superior to that produced by free antigen alone.
Publisher
Dove Medical Press Limited,Taylor & Francis Ltd,Dove Medical Press
Subject
/ Adjuvants, Immunologic - administration & dosage
/ Adjuvants, Immunologic - pharmacology
/ Analysis
/ Animals
/ Antigen-specific humoral response
/ Antigens
/ CD4-Positive T-Lymphocytes - drug effects
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - drug effects
/ CD8-Positive T-Lymphocytes - immunology
/ Dendritic Cells - drug effects
/ Dendritic Cells - immunology
/ Drug Delivery Systems - methods
/ Drugs, Chinese Herbal - administration & dosage
/ Drugs, Chinese Herbal - chemistry
/ Immunity, Cellular - drug effects
/ Immunity, Humoral - drug effects
/ Immunity, Humoral - immunology
/ Lipids
/ Lycium barbarum polysaccharide liposome
/ Mice
/ Nanoparticles - administration & dosage
/ Ovalbumin - pharmacokinetics
/ Vaccines
We currently cannot retrieve any items related to this title. Kindly check back at a later time.