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Gambogic Acid as a Candidate for Cancer Therapy: A Review

by Li, Hui , Lin, Longfei , Chen, Yingchong , Liu, Yuling

in anti-cancer activities / Antineoplastic Agents, Phytogenic - administration & dosage / Antineoplastic Agents, Phytogenic - pharmacology / Apoptosis / Apoptosis - drug effects / Autophagy - drug effects / Breast cancer / Cancer / Cancer therapies / Care and treatment / Cell cycle / combination therapy / Cytochrome / Deoxyribonucleic acid / DNA / Drug Delivery Systems / Drug Resistance, Neoplasm - drug effects / Drugs / gambogic acid / Garcinia - chemistry / Gene expression / Health aspects / Humans / Investigations / Kinases / Lung cancer / Micelles / Mitochondria / Multiple myeloma / Nanostructures / Natural products / Neoplasms - drug therapy / Neoplasms - pathology / Neovascularization, Pathologic - drug therapy / NMR / Nuclear magnetic resonance / Pancreatic cancer / Phosphorylation / Prostate cancer / Proteins / Review / Vehicles / Xanthones - administration & dosage / Xanthones - chemistry / Xanthones - pharmacology

2020

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Gambogic Acid as a Candidate for Cancer Therapy: A Review

by Li, Hui , Lin, Longfei , Chen, Yingchong , Liu, Yuling

2020

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Gambogic Acid as a Candidate for Cancer Therapy: A Review

by Li, Hui , Lin, Longfei , Chen, Yingchong , Liu, Yuling

2020

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Journal Article

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Li, Hui,

Lin, Longfei,

Chen, Yingchong,

Liu, Yuling

2020

Overview

Gambogic acid (GA), a kind of dry resin secreted by the tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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Publisher

Dove Medical Press Limited,Taylor & Francis Ltd,Dove,Dove Medical Press

Subject

anti-cancer activities

/ Antineoplastic Agents, Phytogenic - administration & dosage

/ Antineoplastic Agents, Phytogenic - pharmacology

/ Apoptosis

/ Apoptosis - drug effects

/ Autophagy - drug effects

/ Breast cancer