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Neurobiology of rodent self-grooming and its value for translational neuroscience
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Neurobiology of rodent self-grooming and its value for translational neuroscience
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Journal Article
Neurobiology of rodent self-grooming and its value for translational neuroscience
2016
Overview
Key Points
Self-grooming is an evolutionarily conserved complex innate behaviour that has a role in hygiene maintenance and other physiological functions. Self-grooming is the most frequently occurring awake behaviour in laboratory rodents.
Self-grooming is an important phenotype to study in translational neuroscience, as it may allow the modelling of human diseases that have symptoms similar to, and/or share pathogenetic mechanisms with, aberrant grooming in rodents.
Analysing animal self-grooming also has a broader value in the study of neurobiology underlying complex repetitive behaviours, which may be disrupted in certain neurological diseases.
In this Review, we discuss the neurobiology of grooming, including its underlying circuitry, genetic mechanisms and pharmacological modulation.
We also highlight studies of rodent self-grooming behaviour in models of neuropsychiatric disorders that suggest that it is valuable asset for clinical and translational neuroscience research, including the identification of neural circuits that control complex patterned behaviours.
These findings suggest that the study of rodent self-grooming has multiple implications for translational neuroscience, which may extend beyond understanding the self-grooming behaviour itself.
Rodents spend a large proportion of their waking time engaged in self-grooming behaviour. In this Review, Kalueff and colleagues describe the characteristics and underlying neural circuitry of rodent self-grooming, and discuss its use as a measure of repetitive behaviour in models of psychiatric disease.
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders — including models of autism spectrum disorder and obsessive compulsive disorder — that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.
Publisher
Nature Publishing Group UK,Nature Publishing Group
