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Exosomes released by keratinocytes modulate melanocyte pigmentation
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Exosomes released by keratinocytes modulate melanocyte pigmentation
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Journal Article
Exosomes released by keratinocytes modulate melanocyte pigmentation
2015
Overview
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.
The activity of melanocytes determines skin pigmentation, and is regulated by a tight dialogue with keratinocytes. Here, the authors show that exosomes released by keratinocytes have a direct effect on melanocyte function, and exosome content is dependent on skin phototype and is modulated by ultraviolet B radiation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 14/28
/ 14/63
/ 38
/ Exosomes - radiation effects
/ Gene Expression Regulation - genetics
/ Gene Expression Regulation - radiation effects
/ Humanities and Social Sciences
/ Humans
/ Keratinocytes - radiation effects
/ Keratinocytes - ultrastructure
/ Lipids
/ Melanocytes - radiation effects
/ Melanocytes - ultrastructure
/ Melanosomes - ultrastructure
/ Real-Time Polymerase Chain Reaction
/ Science
