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21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

by Alba, Emilio , Pusztai, Lajos , Barlow, William E , Pierga, Jean-Yves , Lin, Nancy U , Schott, Anne F , Ferrero, Jean-Marc , Jung, Kyung-Hae , Tripathy, Debasish , Miao, Jieling , Chia, Stephen K.L , Kelly, Catherine M , Perez, Edith A , Martin, Miguel , Gil-Gil, Miguel , Gralow, Julie R , Dhesy-Thind, Sukhbinder , Delaloge, Suzette , Hayes, Daniel F , Ramos-Vazquez, Manuel , Lee, Eun-Sook , Bermejo, Begoña , Goldstein, Lori J , Ruiz-Borrego, Manuel , Brain, Etienne G.C , Albain, Kathy S , Shak, Steven , Hortobagyi, Gabriel N , Sharma, Priyanka , Meric-Bernstam, Funda , Kalinsky, Kevin , Arce-Salinas, Claudia H , Rastogi, Priya , Lew, Danika L

in Adult / Age / Aged / Antineoplastic Agents, Hormonal - therapeutic use / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Biopsy / Breast Cancer / Breast Neoplasms - drug therapy / Breast Neoplasms - genetics / Breast Neoplasms - surgery / Cancer therapies / Chemotherapy / Chemotherapy, Adjuvant / Consent / Disease-Free Survival / Endocrine therapy / Epidermal growth factor / ErbB-2 protein / Female / Gene Expression Profiling / Hematology / Humans / Invasiveness / Lymph nodes / Lymphatic Metastasis / Medical prognosis / Menopause / Menstruation / Middle Aged / Neoplasm Recurrence, Local - genetics / Oncology / Population / Post-menopause / Postmenopause / Premenopause / Prospective Studies / Receptor, ErbB-2 / Receptors, Steroid / Reverse Transcriptase Polymerase Chain Reaction / Survival / Treatments in Oncology / Womens health

2021

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21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

2021

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21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

2021

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Journal Article

21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

Alba, Emilio,

Pusztai, Lajos,

Barlow, William E,

Pierga, Jean-Yves,

Lin, Nancy U,

Schott, Anne F,

Ferrero, Jean-Marc,

Jung, Kyung-Hae,

Tripathy, Debasish,

Miao, Jieling,

Chia, Stephen K.L,

Kelly, Catherine M,

Perez, Edith A,

Martin, Miguel,

Gil-Gil, Miguel,

Gralow, Julie R,

Dhesy-Thind, Sukhbinder,

Delaloge, Suzette,

Hayes, Daniel F,

Ramos-Vazquez, Manuel,

Lee, Eun-Sook,

Bermejo, Begoña,

Goldstein, Lori J,

Ruiz-Borrego, Manuel,

Brain, Etienne G.C,

Albain, Kathy S,

Shak, Steven,

Hortobagyi, Gabriel N,

Sharma, Priyanka,

Meric-Bernstam, Funda,

Kalinsky, Kevin,

Arce-Salinas, Claudia H,

Rastogi, Priya,

Lew, Danika L

2021

Overview

Five-year invasive disease–free survival was similar among postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer, one to three positive axillary lymph nodes, and a 21-gene recurrence score of 25 or lower who received endocrine-only therapy and those who received chemoendocrine therapy. In premenopausal women, chemoendocrine therapy significantly improved outcomes.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Age

/ Aged

/ Antineoplastic Agents, Hormonal - therapeutic use

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Biopsy

/ Breast Cancer